Terreic acid biosynthesis
WebBiological Activity for (-)-Terreic acid. (-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC 50 ~ 30 mM) … WebTerreic acid is a quinone epoxide with antibiotic activity. At a mechanism view for its antibiotic action, it inhibits protein synthesis by blocking the formation of leucyl-tRNA in sensitive bacteria [1]. TA was also an inhibitor of Bruton’s tyrosine kinase (Btk) that blocks the PKC-Btk PH domain interaction.
Terreic acid biosynthesis
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Web1 May 2002 · The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),. … Web1 Feb 2024 · Europe PMC is an archive of life sciences journal literature.
Web21 Aug 2024 · In our previous study, we successfully constructed a biosynthetic pathway of terreic acid in P. pastoris . In this pathway, an intermediate product 6 ... Kang HC, Kim JB. … Web25 Sep 2024 · An A. terreus mutant strain was developed (gedCΔ) with a disrupted (+)-geodin biosynthesis pathway. The gedC Δ mutant was created by inserting the antibiotic …
Webeach comonomer comprises a hydrocarbylene group wherein one or more methylene groups of the hydrocarbylene group is optionally replaced by a group Y (provided that none of the Y g
WebPubMed:Molecular Genetic Characterization of Terreic Acid Pathway in Aspergillus terreus. PubMed:Culture-based and sequence-based insights into biosynthesis of secondary …
WebTerreic acid is an effective dose against resistant mutants. It is a natural antimicrobial agent that can be extracted from the acetate extract of terreic acid and has been shown to … quiz for winWeb29 Sep 2014 · Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the … shires optimus dressage saddleWeb7 Jun 2005 · Competitively inhibited by UDP-N-acetylglucosamine 3'-phosphate, with a Ki of 7 uM (PubMed:21445328). In vitro inhibited by covalent binding of fosfomycin and the … quiz for wordsWebTerreic acid (TA) is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme MurA. The survival of most bacteria depends on the functionality of this cytosolic enzyme. The … shires outdoor horse rugsWebWHAT IS CLAIMED IS: 1. A population of heat-inducible macrophages, one or more of said heat-inducible macrophages comprising: a first inducible promoter operably linked to a first polynucleotide comprising a recombinase gene, wherein the first inducible promoter is capable of inducing transcription of the recombinase gene to generate a recombinase … shires outdoor rugsWebTracer studies using the 14C-labeled salts of acetic acid, 6-methylsalicylic acid, and orsellinic acid demonstrate that the carbon skeleton of terreic acid (3,4-epoxy-6-hydroxy … quiz for year 4 childrenWeb18 May 2010 · Terreic acid is a metabolite with antibiotic properties produced by the fungus Aspergillus terreus.We found that terreic acid is a covalent inhibitor of the bacterial cell … quiz for writers