Sparc/osteonectin in mineralized tissue

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August undefined, 2024

WebHigher intratumoral uptake of nab-paclitaxel may, in part, be a result of overexpression of matricellular albumin-binding protein (secreted protein acidic and rich in cysteine [SPARC]) in some malignancies. 18,19 SPARC (also called as osteonectin or basement membrane protein 40) is a nonstructural matricellular calcium-binding glycoprotein ... WebThe function of SPARC in mineralized tissues both during homeostasis and disease has yet to be fully defined, however a significant amount of insight into SPARC activity in …

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WebSPARC (secreted protein acidic and rich in cysteine, also known as osteonectin or BM-40) is a widely expressed profibrotic protein with pleiotropic roles, which have been studied in a variety of conditions. Notably, SPARC is linked to human obesity; SPARC derived from adipose tissue is associated wi … WebThe glycoprotein BM-40 (also termed SPARC, osteonectin) is a secreted protein widely distributed in human and murine tissues. It has been identified in bone, where it is one of the major noncollagenous glycoproteins, in basement membranes, and in several other extracellular tissues (Termine et al, 1981; Dziadek et al, 1986; Sodek, 1993). Several … john dewey theory of learning

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Web1. jan 2024 · SPARC/osteonectin in mineralized tissue. Article. Feb 2016; Emilie Moore Rosset; Amy Bradshaw; Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non ... Web3. apr 2024 · Osteonectin (SPARC, BM-40) is another non-collagenous protein occurring in mineralized tissues; its expression is closely aligned with Col1 expression. It is secreted by osteoblasts during bone formation. WebThe successful use of transcriptional targeting for cancer therapy depends on the activity of a given promoter inside the malignant cell. Because solid human tumors evolve as a “cross-talk” between the different cell types within the tumor, we intents adres

SPARC/Osteonectin in Mineralized Tissue - PMC - National Center …

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Web25. nov 2024 · The SPARC gene (Secreted Protein Acidic and Rich in Cysteine, formerly coined Osteonectin) encodes a matricellular protein which is one of the most abundant non-collagenous matrix proteins in mammalian and teleost bone (Schreiweis et al., 2007; Kessels et al., 2014).Secreted by osteoblasts, the SPARC protein functions in mineralized tissues … WebThe SPARC/Osteonectin secreted by a human osteosarcoma cell line (MG63) was also tested. In all the nonmineralized tissues tested (gut, bone marrow, tendon, mesentery, … john dewey\\u0027s continuity and interaction rrlWebSPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix … intent recognition using bert

"Web6. aug 2009 · Osteopontin (OPN) and osteonectin/SPARC (ON/SPARC) are prominent matricellular components of the extracellular matrix of mineralized tissues of bones and teeth in which they can regulate the formation and growth of hydroxyapatite crystals and influence a variety of cell activities. " - Sparc/osteonectin in mineralized tissue

Sparc/osteonectin in mineralized tissue

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Web7. dec 2024 · Osteonectin (ON) is an important non-collagenous protein, also known as SPARC (secreted protein acidic and rich in cysteine) or BM‐40, and it has a high affinity for binding with collagen and hydroxylapatite []; ON also participates in the overall osteoblast mineralization process [] and plays an important role as a type of functional regulatory … Web13. apr 2024 · HIGHLIGHTS. who: Nathalie Ringstru00f6m and collaborators from the Faculty of Health and Medical Science, University of Surrey, Guildford , AL, UK have published the article: Framing Heartaches: The Cardiac ECM and the Effects of Age, in the Journal: (JOURNAL) of 10/02/2024 SUMMARY

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Web8. jan 2024 · Diverse pathologies (inflammation, tissues injuries, cancer, etc.) and physiological conditions (obesity, physical activity, etc.) induce the expression/secretion of the matricellular protein, secrete protein acidic and rich in cysteine (SPARC). SPARC contributes to the creation of an environment that is suitable for tissue regeneration … WebThe glycoprotein SPARC (secreted protein, acidic and rich in cysteine), also termed osteonectin, BM-40, and 43 K protein, has been classified, along with tenascin and …

WebAn autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. ... PTHR13866:SF6 SPARC 1 hit; PTHR13866 SPARC OSTEONECTIN 1 hit; PROSITE. View protein in PROSITE; PS00018 EF_HAND_1 1 hit; PS51465 KAZAL_2 1 hit; PS00612 ... WebSouthern blot analysis revealed SPARC as a low or single-copy gene in an evolutionary diverse group of vertebrates, and data suggest that SPARC has multiple functions in …

Webor search citations ... WebThe temporal and spatial distribution of osteonectin/SPARC was investigated during different stages of human development by in situ hybridization and histochemistry …

Web1. apr 1991 · Expression of SPARC/osteonectin in tissues of bony and cartilaginous vertebrates. ...

WebSPARC is a secreted glycoprotein that modulates cell shape and cell-matrix interactions. Levels of SPARC are increased at sites of somitogenesis, osteogenesis, and angiogenesis … intents carnavalWebRosset, E. M., & Bradshaw, A. D. (2016). SPARC/osteonectin in mineralized tissue. Matrix Biology, 52-54, 78–87. doi:10.1016/j.matbio.2016.02.001 john dewhirstWeb骨形成蛋白-马刚-中文期刊【掌桥科研】 ... 无 john dewey the ethics of democracyWebOsteonectin (ON), also called SPARC or BM40, is a non-collagenous calcium binding protein of bone matrix expressed in mineralized tissues including endothelial cells and … john dewey theory on educationWeb30. júl 2004 · Secreted protein, acidic, rich in cysteine (SPARC)/osteonectin/BM40 is a multifunctional calcium-binding glycoprotein first identified as a major non-collagenous component of bovine mineralized tissues (Termine et al. 1981).Numerous studies have since demonstrated that SPARC is expressed by a broad spectrum of adult tissues and … intents and entities in chatbotWeb22. júl 2004 · Mineralized tissue is a critical innovation in vertebrate evolution, offering the basis for various adaptive phenotypes: body armor for protection, teeth for predation, and endoskeleton for locomotion. Two distinct types of mineralized tissues emerged in Paleozoic agnathans: tooth-like oral skeleton and dermal skeleton ( 1 – 4 ). intents calculator discord.jsWeb1. feb 2016 · Sparc, also known as osteonectin or basement membrane protein 40, is one of the most abundant collagenous proteins in bone [31]. Sparc is expressed in both … john dewitsky attorney