Iph4102-102
WebA phase II clinical trial (NCT03902184) is ongoing investigating IPH4102 as a single agent or in combination with chemotherapy in treating T-cell lymphomas. LIRs (ILTs) Leukocyte immunoglobin-like receptor (LIR) or immunoglobin-like transcript (ILT), like KIR, belongs to the Ig superfamily and consists of activating as well as inhibitory receptors ( 53 , 101 , 102 ). Web1 aug. 2024 · IPH4102 is a first-in-class monoclonal antibody targeting KIR3DL2, a cell surface protein that is expressed in cutaneous T-cell lymphoma, and predominantly in its leukaemic form, Sézary syndrome. We aimed to assess the safety and activity of IPH4102 in cutaneous T-cell lymphoma. Methods
Iph4102-102
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WebIPH4102 is a first-in-class anti-KIR3DL2 humanised cytotoxicity-inducing antibody being developed to treat patients suffering from cutaneous T-cell lymphoma (CTCL). The investigational candidate secured orphan drug designation in the US and Europe for CTCL. Web1 jun. 2024 · IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open …
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Web6 dec. 2024 · TELLOMAK is a global, open-label, multicohort Phase II clinical trial conducted in the United States and Europe. In this trial, IPH4102 is evaluated alone and in …
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