Identification of hub genes and pathways

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August undefined, 2024

Web23 mei 2024 · The hub genes found in our study were associated with several important pathways related to CRC, such as the p53 signaling pathway. Additionally, some hub genes having a link with oxidative stress and apoptosis pathways were identiﬁed. WebZhan, Z., Chen, Y., Duan, Y., Li, L., Mew, K., Hu, P., … Peng, M. (2024). Identification of key genes, pathways and potential therapeutic agents for liver fibrosis ...

Identification of Hub Genes in Prostate Cancer by Bioinformatics …

WebMicroarray analysis was used to identify the differentially expressed genes. Bioinformatics analyses integrated with databases and text-mined gene network were conducted to understand irradiation-related hub genes, pathways and biological processes. Our hypothesis in these paper are: 1) the expression profiles of irradiation damaged bone … Web10 apr. 2024 · Prostate cancer (PCa) is the second most common cause of cancer death in American men. Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal form of PCa and preferentially metastasizes to the bones through incompletely understood molecular mechanisms. Herein, we processed RNA sequencing data from patients with … paying tuition credit card sb

Sci-Hub Identification of Key Genes and Pathways in Myeloma …

Web20 aug. 2024 · We use the methods mentioned above to identify hub genes. 143 hub genes in the three modules were identified. Figure 3 shows the PPI network for modules which … Web12 aug. 2024 · The purpose of this study was to explore hub genes and pathways related to IPF development and prognosis. Multiple gene expression datasets were downloaded … Web7 sep. 2024 · Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy worldwide. However, the molecular events underlying IgAN remain to be fully elucidated. This study aimed to identify novel biomarkers of IgAN through bioinformatics analysis and elucidate the possible molecular mechanism. Based on the … screwfix uk cwmbran

Identification of Hub Genes in Different Stages of Colorectal …

Biology Free Full-Text Identification of Critical Genes for Ovine ...

Web23 mei 2024 · Colorectal cancer (CRC) is the third most common cancer that contributes to cancer-related morbidity. However, the differential expression of genes in different phases of CRC is largely unknown. Moreover, very little is known about the role of stress-survival pathways in CRC. We sought to discover the hub genes and identify their roles in … WebAxon guidance, proteoglycans in cancer and mitogen-activated protein kinases (MAPK) signaling pathway were common pathways in these three modules. Keratin18 (KRT18) … paying tuition fees university of liverpoolWebThe top 10 hub genes were JUN, FOXO3, CASP3, JAK2, RELA, EZH2, ABL1, PTGS2, FBXW7, MCL1. Besides, TFAP2A, GATA2, SP1, and E2F1 may be the key regulatory … screwfix uk cordless drills

"WebIdentification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification. This … " - Identification of hub genes and pathways

Identification of hub genes and pathways

Identification of common pathway and hub genes in the …

Web11 apr. 2024 · Cytoscape software was used to identify hub genes and identify common hub genes by taking intersection sets. ... Li et al. (2024a) reported that the differential gene expression, signaling pathways involved, and signature enrichment profiles obtained differed significantly by the proportion of cell types in different datasets. Web27 mrt. 2024 · These DEGs were mainly involved in mTOR signaling pathway and the NOD-like receptor signaling pathway. The top 10 hub genes were CAT, GAPDH, …

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Web7 sep. 2024 · Venn diagram, PPI network and the most significant module of DEGs. a DEGs were selected with a fold change > 0.5 and P-value < 0.05 among the mRNA expression profiling sets GSE8401, GSE46517 and GSE7956.The 3 datasets showed an overlap of 120 genes. b The PPI network of DEGs was constructed using Cytoscape.c The most … Web1 jun. 2024 · Screening of hub genes by survival analysis Since the hub genes, including PECAM1, TEK, CDH5, VWF and ANGPT1, were identified as the most notable …

WebIdentification of Hub Genes Between DM and PC. DM has been identified as a risk factor for PC. We therefore tried to identify hub genes between DM and PC by analyzing the … Web8 aug. 2024 · Methods: We downloaded the GSE15061 gene expression dataset from the Gene Expression Omnibus database and used weighted gene co-expression network …

WebIdentification of key genes and pathways in seminoma by bioinformatics analysis Ye-Hui Chen, Ting-Ting Lin, Yu-Peng Wu, Xiao-Dong Li, Shao-Hao Chen, Xue-Yi Xue, Yong Wei, Qing-Shui Zheng, Jin-Bei Huang, Ning XuDepartments of Urology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, People’s Republic of … WebCorrespondence: ZhaoHui Fang; GuoMing Shen Tel +86-13085513100. Email [email protected]; [email protected]. Background: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in the world with complicated pathogenesis. This study aimed to identify differentially expressed genes (DEGs) and …

Web12 apr. 2024 · Combined with the logFC values of the hub genes in the GSE38959 dataset, the GO and KEGG enrichment pathways were analyzed. The top 10 GO terms and KEGG pathways are shown in Figure 4. In the BP category, nine hub genes including CYBB, NCF1, NCF2, ITGB2, RAC2, ITGAM, CYBA, ICAM1, and TLR4 were enriched in reactive …

Web20 feb. 2024 · This study was designed to identify the potential key protein interaction networks, genes, and correlated pathways in early-onset colorectal cancer (CRC) via bioinformatics methods. We selected microarray data GSE4107 consisting 12 patient’s colonic mucosa and 10 healthy control mucosa; initially, the GSE4107 were downloaded … paying tulsa county property taxesWeb21 dec. 2024 · Among the six hub genes, CD3D, CD3E, GRAP2 and ITK were significantly associated with the overall survival of TNBC (log-rank P < 0.05; Figure 5A–D). … paying tuition with credit card for pointsWeb13 apr. 2024 · Pathway analysis revealed that the Wnt signaling pathway may be responsible for horn development. Further, through combining the protein–protein interaction networks of the DEGs, it was found that the top five hub genes, namely, ACAN, SFRP2, SFRP4, WNT3, and WNT7B, were also associated with horn development. paying tuition fees uobWeb13 apr. 2024 · Hub gene identification is a meaningful way to obtain biological information because these genes are remarkably connected with other genes in the PPI. ... Genes and pathways enriched with the shared signatures are shown on the right. Top hit upregulated and downregulated genes are shown in red and blue, respectively. paying tv licence by bacsWeb19 jul. 2024 · To provide a better understanding of dementia at the molecular level, this study aimed to identify the genes and key pathways associated with dementia by using integrated bioinformatics analysis. Based on the expression profiling by high throughput sequencing dataset GSE153960 derived from the Gene Expression Omnibus (GEO), the … paying turbotax with federal refundWebCausal genes and pathways for the remaining 76 loci remain unknown to date. Here we argue that cell-type heterogeneity of the eQTL dataset, in addition to the sample size limitation, are the key contributors to the low yield of identifying causal genes for CKD using the GWAS-eQTL integration approach 24,33–35. paying tv licence feeWebThe purpose of this study was to explore hub genes and pathways related to IPF development and prognosis. Multiple gene expression datasets were downloaded from … paying tv licence by phone