WebJul 1, 2002 · Pertussis toxin (PT) has been widely used to facilitate the induction of experimental autoimmune encephalomyelitis (EAE) in rodents. It has been suggested that this microbial product promotes EAE by opening up the blood-brain barrier and thereby facilitates the migration of pathogenic T cells to the CNS. WebMay 12, 2024 · EAE was induced in 12 6–8 weeks old female C57BL/6 mice using myelin oligodendrocyte glycoprotein (MOG) peptide. FUS-induced BBBD was performed 6, 7, and 9 days after immunization in subgroups of four animals and in an additional control group. MRI and MRE were performed on a 7T horizontal bore small animal MRI scanner.
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WebJul 7, 2024 · Treatments were given to mice as 100 μl injections in the tail vein (i.v.) every second day, starting on day 2 after EAE induction, under isoflurane anesthesia (4% induction, 2–3% maintenance). Dex groups received a dose of approximately 4.3 mg/kg of dex (D1159, Sigma) from 2 to 16 dpi, and 5 mg/kg from 16 to 28 dpi. WebExperimental autoimmune encephalomyelitis (EAE) is the most commonly used experimental model for the human inflammatory demyelinating disease, multiple … slug in yoast seo
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WebEAE models are induced via injection of myelin oligodendrocyte glycoprotein (MOG) or proteolipid protein (PLP). Disease course and the effect of novel therapeutics are then examined over several weeks. Validated for rats and mice, our EAE models allow you to effectively evaluate novel MS therapies that target the inflammatory response: MOG35 … WebExperimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune disease of the CNS that causes the CNS myelin to be recognized as an exogenous … WebMay 15, 2024 · Experimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple sclerosis model. Here, we compare clinical, cellular and molecular properties b … slug is a unit of