WebAug 27, 2024 · The DELIVER trial (Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure) compared dapagliflozin with placebo in patients with mildly reduced or preserved ejection fraction (LVEF >40%). 10 The trial enrolled patients over a broad range of ages from 40 to 99 years. This prespecified … WebAug 25, 2024 · Among patients with heart failure (HF) and a mildly reduced or preserved ejection fraction, dapagliflozin resulted in a lower risk of worsening HF or cardiovascular death compared with placebo, according to findings from the DELIVER trial. The results, presented at ESC Congress 2024 and simultaneously published in the New England …
Dapagliflozin in heart failure with improved ejection fraction: a ...
WebAug 27, 2024 · Post hoc analyses of a large-scale trial of dapagliflozin in type 2 diabetes indicated that SGLT2 inhibition might not reduce the incidence of serious adverse … Web2 days ago · Patients with heart failure with minimally reduced ejection fraction (HFmrEF) or heart failure with preserved ejection fraction (HFpEF) have a significant burden of symptoms, physical limitations, and low quality of life; thus, one of the main therapeutic objectives is to improve health status. cst berger tripod parts list
Dapagliflozin in heart failure with preserved and mildly reduced ...
WebMay 5, 2024 · The phase 3 DELIVER trial has met its primary endpoint, with use of dapagliflozin (Farxiga) associated with a statistically significant and clinically meaningful reduction in the primary composite endpoint of cardiovascular death or worsening heart failure in patients with heart failure with mildly reduced or preserved ejection fraction, … WebSep 14, 2024 · Presented at HFSA 2024, PRESERVED-HF provides evidence suggesting dapagliflozin use was associated with improvements in KCCQ symptom score and 6-minute walking distance in patients with heart failure with preserved ejection fraction. Mikhail Kosiborod, MD WebApr 1, 2024 · The classification of HF is as follows: HFrEF (HF with reduced ejection fraction [EF]): LVEF ≤40%; HFimpEF (HF with improved EF): Previous LVEF ≤40% and follow-up measurement of LVEF >40%; HFmrEF (HF with mildly reduced EF): LVEF 41-49%; HFpEF (HF with preserved EF): LVEF ≥50%. cst berger transit level manual