WebGenomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. WebNov 18, 2024 · We show that reactivation of HIV is associated with downregulation of the key H 2 S producing enzyme cystathionine-γ-lyase (CTH) and reduction in endogenous H 2 S. Genetic silencing of CTH disrupts redox homeostasis, impairs mitochondrial function, and remodels the transcriptome of latent cells to trigger HIV reactivation.
UniProt
WebOct 5, 2024 · Hydrogen sulfide (H 2 S), as an endogenous gaseous signaling molecule, plays an important role in the inflammatory process. Our previous study found that … WebSep 4, 2024 · Besides playing crucial roles in metabolism of sulfur-containing amino acid, CBS is a prominent enzyme for the production of hydrogen sulfide (H 2 S) which is considered a critical signaling... arberlandbahn
Cth cystathionase (cystathionine gamma-lyase) [ (house mouse)]
WebFeb 7, 2024 · 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function. These … WebJan 29, 2024 · Autophagy. 2024 Jan 28:1-18. doi: 10.1080/15548627.2024.2026097. Online ahead of print.ABSTRACTVascular smooth muscle cells (VSMCs) contribute to plaque stability. VSMCs are also a major source of CTH (cystathionine gamma-lyase)-hydrogen sulfide (H2S), a protective gasotransmitter in atherosclerosis. WebJan 10, 2003 · By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation … bakery 32819