WebAug 3, 2016 · BIN1 is the most significant late-onset AD susceptibility locus identified via the genome-wide association studies. Multiple BIN1 isoforms are expressed in the human … WebNov 15, 2009 · Efficacy of Bin1 RNAi was confirmed by immunoblotting of HeLa cell lysates with anti-BIN1 antibodies. Efficient knockdown of up to 80 to 90% was achieved as observed by loss of BIN1-specific bands.

Bridging integrator 1 (BIN1): form, function, and Alzheimer

WebBin1 MEDIATES APOPTOSIS BY c-Myc however, deletion of the Bin1 gene in transformed mouse fibroblasts or in the fission yeast Schizosaccharomyces pombe results in defective apoptotic signaling or cell cycle control, respectively, but not in grossly altered cytoskeletal actin or endocytosis, suggesting that a full understanding of Bin1 function ... WebOct 1, 2013 · BIN1 is the second most important risk locus for LOAD, after APOE. • BIN1 affects AD risk primarily by modulating tau pathology. • BIN1 is also involved in … mn special operations training association

Association analysis of polymorphisms in BIN1, MC1R, STARD6

WebBin1 expression or Bin1–Myc interaction specifically inhibited Myc-mediated apoptosis [28,29]. Similarly, the essential role for BIN1 in oncogene-induced senescence in primary cells was identified [30], which also helps restrict cancer at its earliest stages. Genetics of BIN1 gene in AD The BIN1 gene locus was initially identified as ... WebBIN1 functions in clathrin-mediated endocytosis and endocytic recycling, as does the AD risk gene PICALM. Whereas brain-specific isoforms may be involved in the retrieval of … WebThe bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset Alzheimer's disease (LOAD), … mn speakers showcase